About the journal
The Journal of Insulin Resistance, launched this year, is a peer-reviewed, open access clinically oriented journal published by AOSIS which covers advances in disorders of insulin resistance. Articles will focus on clinical care and advancing therapy for patients with insulin resistance-related disorders, such as obesity, metabolic syndrome, type 2 diabetes, cardiovascular disease, non-alcoholic steatohepatitis, Alzheimer’s dementia and sexual dysfunction. Insulin resistance includes pathophysiology, management, patient education and treatment considerations for different patient populations.
About the article
The first article to be published in this new journal is ‘Added sugars drive chronic kidney disease and its consequences: A comprehensive review’, which discusses how consumption of added sugars (e.g. sucrose [table sugar] and high-fructose corn syrup) over the last 200 years has increased exponentially, paralleled by increased prevalence of chronic kidney disease (CKD). Data for animals and humans suggest that consumption of added sugars leads to kidney damage and related metabolic derangements that increase cardiovascular risk.
Importantly, consumption of added sugars has been found to induce insulin resistance and increase uric acid in humans, both of which increase conversion of glucose to fructose (i.e. fructogenesis) via the polyol pathway. The polyol pathway has recently been implicated in contributing to and progression of kidney damage, suggesting that even glucose can be toxic to the kidney via its endogenous transformation into fructose in the proximal tubule.
Consuming added fructose has been shown to induce insulin resistance, which can lead to hyperglycaemia, oxidative stress, inflammation and activation of the immune system, all of which can synergistically contribute to kidney damage. CKD guidelines should stress a reduction in consumption of added sugars as a means to prevent and treat CKD as well as reduce CKD–related morbidity and mortality.
About the author
The author of this first article is Dr James J. DiNicolantonio, a Cardiovascular Research Scientist at Saint Luke’s Mid America Heart Institute in Kansas City, Missouri, USA. Dr DiNicolantonio’s research interests focus on cardiovascular health and disease, including topics such as diabetes, obesity, hypertension, insulin resistance, lipids, antithrombotics, anticoagulants, as well as nutrition (with particular focus on refined sugars and salt) and nutritional supplements. He is author or co-author of over 175 medical publications, and serves as Associate Editor of British Medical Journal’s (BMJ) Open Heart, which is published in partnership with the British Cardiovascular Society. Dr DiNicolantonio also serves as a frequent reviewer for several medical journals, and is on the editorial advisory board of a number of medical journals including the International Journal of Clinical Pharmacology & Toxicology (IJCPT), CIP Journal of Cardiology, and Progress in Cardiovascular Diseases.
About AOSIS Publishing
AOSIS Publishing provides comprehensive and personal publishing services for scholarly journals, scholarly books and conference proceedings. As an open access publisher it offers high-quality scholarly publications and is committed to disseminate peer-reviewed research across a range of academic disciplines.