South African researchers Prof Phumla Sinxadi and Dr Enkosi Mondleki recently discussed their research article titled ’Effect of obesity on dolutegravir exposure in Black Southern African adults living with HIV’, which was published in the Southern African Journal of HIV Medicine.
Dolutegravir, a component of the preferred first-line antiretroviral therapy regimen, has been associated with increased weight gain. South Africa has a high prevalence of obesity, especially among women. Understanding dolutegravir exposure in patients with obesity is important for dose optimisation.
The study enrolled 40 participants, of which 26 were women and 10 had obesity. The results showed that dolutegravir exposure was marginally lower in participants with obesity, but this difference is not clinically significant. The researchers found that there is no need to adjust the dolutegravir dose in people with obesity.
The article’s abstract can be accessed through the Southern African Journal of HIV Medicine website, while the full article can be downloaded from the following link: https://bit.ly/42sC6Bl. This study represents another great contribution to the important field of HIV medicine and highlights the need for personalized care.
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Watch now: Insightful discussion on the effects of obesity on dolutegravir exposure in adults with HIV
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