The Journal of Medical Laboratory Science & Technology of South Africa

• The histopathological spectrum of cholecystectomy tissue samples at an academic laboratory in Northern Pretoria, South Africa 23rd November 2025
  Introduction: Cholecystectomy, the surgical removal of the gallbladder, is commonly performed to treat gallstones (cholelithiasis). These stones, primarily composed of cholesterol or bilirubin, can lead to symptoms ranging from mild discomfort to severe complications. Cholelithiasis is also one of the risk factors for gallbladder carcinoma. Histopathological examination of gallbladder specimens is crucial in understanding disease […]
  L. N. Mhlongo
• Coming full circle: a prospective comparison of the South African and International Society on Thrombosis and Haemostasis protocols for dilute Russell's viper venom testing 23rd November 2025
  Introduction: Antiphospholipid syndrome (APS) is an autoimmune condition typified by a propensity to thrombosis and pregnancy loss. Dilute Russell’s viper venom testing (DRVVT) is an important cornerstone for APS diagnosis. International guidelines differ in the laboratory protocol for DRVVT, particularly regarding the timing and employment of mixing studies. This study aimed to prospectively compare the result […]
  J. Vaughan
• Unscrambling the secretor and non-secretor phenotypes by exploring chromosome 19's genetic musketeers – H, Se and Le genes 23rd November 2025
  The presence or lack of ABO blood group antigens in bodily secretions is explained by interesting genetic differences that give rise to the secretor and non-secretor phenotypes. The three genes on chromosome 19, namely H, Se, and Le (the genetic musketeers), have a significant impact on the secretor status. This review aimed to comprehensively explore the complex link between […]
  P. H. Mfengwana
• Mitigating possible shortages: validating blood collection tubes for therapeutic drug monitoring 23rd November 2025
  Background: This study was conducted at a National Health Laboratory Service (NHLS) regional laboratory in response to possible shortages of blood collection tubes supplied by Becton Dickinson (BD).Aim: The study aimed to evaluate four alternative tubes available in South Africa to seek one suitable for therapeutic and toxic drug monitoring (TDM).Methods: After ethical approval, 50 healthy adult volunteers […]
  A. A. Khine
• Correlation between genotypes and antifungal susceptibility profiles of Candida isolates from pregnant and non-pregnant women in South Africa 23rd November 2025
  Vulvovaginal candidiasis (VVC) is a common vaginal infection, affecting up to 75% of women of reproductive age at some point in their lives. The leading cause of VVC is Candida albicans (C. albicans). This study investigates the correlation between genotypes and antifungal susceptibility profiles of Candida isolates collected from pregnant and non-pregnant South African women. A total of 72 Candida isolates […]
  C. Ramnarain